| Control | CWAT | CWAT +  | Treatment effects | |||||
---|---|---|---|---|---|---|---|---|---|
 | Baseline (n = 20) | 12 weeks (n = 19) | Baseline (n = 20) | 12 weeks (n = 20) | Baseline (n = 19) | 12 weeks (n = 17) | CWAT vs. control | CWAT +  vs. control | CWAT +  vs. CWAT |
Cardiovascular health | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Systolic BP (mm Hg) | 120 ± 13 | 117 ± 12 | 123 ± 12 | 120 ± 12 | 124 ± 12 | 125 ± 15 | 1 (− 6, 8) | 4 (− 3, 12) | 3 (− 4, 10) |
 Diastolic BP (mm Hg) | 79 ± 8 | 77 ± 7 | 83 ± 9 | 80 ± 8 | 81 ± 8 | 81 ± 9 | 0 (− 4, 4) | 3 (− 1, 6) | 3 (− 1, 6) |
 Mean arterial pressure (mm Hg) | 93 ± 10 | 90 ± 8 | 96 ± 9 | 93 ± 9 | 95 ± 9 | 96 ± 10 | 0 (− 4, 5) | 3 (− 1, 8) | 3 (− 2, 7) |
 Resting heart rate (bpm) | 62 ± 6 | 61 ± 7 | 59 ± 9 | 60 ± 8 | 57 ± 7 | 60 ± 8 | 1 (− 4, 6) | 3 (− 2, 8) | 2 (− 3, 6) |
 Total cholesterol (mmol/l) | 5.00 ± 0.93 | 4.80 ± 0.91 | 5.40 ± 1.12 | 4.78 ± 0.88 | 5.67 ± 1.27 | 4.64 ± 0.98 | − 0.17 (− 0.79, 0.45) | − 0.41 (− 1.06, 0.24) | − 0.24 (− 0.87, 0.39) |
 HDL cholesterol (mmol/l) | 1.39 ± 0.24 | 1.26 ± 0.33 | 1.62 ± 0.49 | 1.36 ± 0.23 | 1.61 ± 0.51 | 1.26 ± 0.29 | 0.07 (− 0.14, 0.28) | − 0.05 (− 0.25, 0.18) | − 0.11 (− 0.31, 0.10) |
 LDL-cholesterol (mmol/l) | 3.61 ± 0.82 | 3.54 ± 0.81 | 3.78 ± 1.10 | 3.42 ± 0.90 | 4.06 ± 0.98 | 3.38 ± 0.82 | − 0.20 (− 0.67, 0.27) | − 0.38 (− 0.87,0.11) | − 0.18 (− 0.67, 0.31) |
 Triglycerides (mmol/l) | 0.98 ± 0.41 | 1.05 ± 0.55 | 1.25 ± 0.71 | 1.02 ± 0.57 | 1.22 ± 0.38 | 0.94 ± 0.37 | − 0.25 (− 0.55, 0.05) | − 0.31 (− 0.62, − 0.01)* | − 0.07 (− 0.63, 0.23) |
Glucose tolerance | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Fasting glucose (mmol/l) | 5.3 ± 0.5 | 5.2 ± 0.5 | 5.1 ± 0.7 | 5.2 ± 0.5 | 5.3 ± 0.4 | 5.5 ± 1.0 | 0.3 (− 0.5, 0.5) | 0.2 (− 0.3, 0.7) | 0.2 (− 0.3, 0.7) |
 Fasting insulin (pmol/l) | 60 ± 31 | 55 ± 24 | 54 ± 35 | 46 ± 29 | 44 ± 28 | 52 ± 17 | − 5 (− 20, 10) | 5 (− 11, 21) | 10 (− 5, 25) |
 Glucose 120 min (mmol/l) | 6.5 ± 1.8 | 7.3 ± 2.3 | 6.2 ± 1.7 | 6.4 ± 1.9 | 6.9 ± 1.7 | 6.6 ± 1.5 | − 0.3 (− 1.6, 0.9) | − 0.6 (− 1.9, 0.7) | − 0.3 (− 1.6, 1.0) |
 Insulin 120 min (pmol/l) | 547 ± 389 | 571 ± 425 | 490 ± 429 | 421 ± 396 | 551 ± 433 | 371 ± 241 | − 68 (− 266, 129) | − 173 (− 375, − 29)* | − 104 (− 304, 95) |
 Glucose tAUC (mmol/l min) | 862 ± 159 | 903 ± 209 | 832 ± 155 | 845 ± 196 | 890 ± 139 | 862 ± 180 | − 2 (− 132, 127) | − 60 (− 192, 72) | − 57 (− 194, 79) |
 Matsuda index | 5.04 ± 3.42 | 5.45 ± 3.51 | 6.07 ± 3.71 | 7.13 ± 4.59 | 5.75 ± 2.37 | 5.18 ± 1.72 | 0.27 (− 1.70, 2.24) | − 0.65 (− 2.70, 1.40) | − 0.91 (− 2.94, 1.11) |
 IGI | 209 ± 151 | 178 ± 109 | 173 ± 155 | 183 ± 165 | 113 ± 201 | 156 ± 81 | − 9 (− 53, 71) | 6 (− 59, 72) | − 3 (− 67, 62) |
 QUICKI | 0.35 ± 0.03 | 0.36 ± 0.04 | 0.36 ± 0.04 | 0.37 ± 0.04 | 0.37 ± 0.03 | 0.35 ± 0.02 | 0.01 (− 0.01, 0.03) | − 0.02 (− 0.04, 0.00)* | − 0.03 (− 0.05, 0.01)* |
 HOMA-IR | 2.07 ± 1.16 | 1.88 ± 0.93 | 1.86 ± 1.40 | 1.55 ± 1.07 | 1.54 ± 1.11 | 1.90 ± 0.91 | − 0.19 (− 0.79, 0.42) | 0.30 (− 0.34, 0.93) | 0.49 (− 0.14, 1.11) |
 mISI | 0.11 ± 0.08 | 0.13 ± 0.1 | 0.14 ± 0.10 | 0.18 ± 0.19 | 0.14 ± 0.08 | 0.16 ± 0.08 | 0.03 (− 0.09, 0.14) | 0.03 (− 0.09, 0.15) | 0.00 (− 0.12, 0.12) |
 HIRI | 32.8 ± 11.0 | 34.0 ± 13.0 | 32.2 ± 13.0 | 31.7 ± 13.5 | 27.7 ± 10.7 | 30.1 ± 6.7 | − 1.0 (− 7.2, 5.2) | − 0.8 (− 7.3, 5.7) | 0.2 (− 6.2, 6.6) |